In the 18th century, the debate about the best method for understanding nature is directly linked to the problem of the ontological status of nature itself. As different as the theories on the subject were, two characteristics of nature were consensual: space and time. Defining what they are and how these concepts relate to the objects of the senses has become an essential theme within the philosophical theory of some authors, to whom we choose Kant and Newton. Faced with some similarities that these two thinkers have about the concepts of space and time, we seek to investigate whether Kant's work, with regard to this debate, represents an advance in relation to Newton's work, both in terms of understanding the nature of space and of time considered in themselves as well as in their internal relationship with the other elements of the author's thought. In order to do so, as main sources of research we make use, at first, of the Leibniz-Clarke Correspondence, as we believe we find in them a greater detail of the Newtonian concepts of space and time, defended by Clarke and, in a second moment, we move on to the works of Kant that deal directly with the subject, with emphasis on the Critique of Pure Reason. In the end, we can verify that there is a significant difference between the authors, and we list them in ten, ranging from the priority of the approach of philosophical themes to the very conception of nature for the authors and the foundation of the idea of nature that each one has. exactly like the big difference between them. The Kantian concept of nature in general presents itself as the one that brings together all the elements presented by Kant in his epistemology, which places the subject as the center of philosophical reflection and also of all nature. The concepts of space and time, as belonging to the subject, represent both the condition and the limit of all possible nature.
Key-words: Kant; Newton; Space and Time; Nature; Transcendental Aesthetics.